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Glucovance is an oral antihyperglycemic drug that contains Glyburide and Metformin HCl. GLYBURIDE helps to treat type 2 diabetes. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Along with its needed effects, glyburide/metformin may cause some unwanted effects. Mar 02, 2017 · Hi, New here, I was switched from Glyburide to Metformin XR at the beginning of December due to the formulary on my Insurance changing. It’s important to know about all the drugs in the combination because each drug may affect you in a different way Compare prices and print coupons for Glyburide / Metformin (Generic Glucovance) and other Diabetes Type 2 drugs at CVS, Walgreens, and other pharmacies. Glyburide belongs to a group of drugs called sulfonylureas Glyburide is used to treat type 2 diabetes, either alone or in combination with other diabetes medications, such as metformin. Januvia Glyburide Metformin. 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